Michiel Vanhooydonck

I joined the CallewaertLab as a PhD student in 2020 with a background as a bio-science engineer. My research expertise lies in the intersection of genetic engineering and cardiovascular science. Specifically, my work is focused on elucidating the molecular mechanisms underpinning aortic dissection and rupture, with a particular emphasis on the roles played by SMAD3 and SMAD6 loss of function in the zebrafish model system. In addition to my core research, my efforts encompass the refinement and optimization of gene-editing techniques in order to introduce specific point mutations in the zebrafish genome. This critical methodology is instrumental in generating exact and controlled genetic modifications, enabling a more comprehensive exploration of the genetic factors associated with cardiovascular diseases. The insights derived from our research have the potential not only to advance our understanding of aortic pathologies but also to provide valuable knowledge for the development of targeted clinical interventions in the future.